CasNo： 102767-28-2
MF： C8H14N2O2
Appearance： White crystalline powder
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General Description |
Chemical 102767-28-2, also known as Resmethrin, is a synthetic pyrethroid insecticide and acaricide used for the control of a wide range of household and agricultural pests. It is commonly formulated as an aerosol spray or fogger for indoor pest control and is effective against mosquitoes, flies, ants, and cockroaches. Resmethrin works by disrupting the function of the nervous system in insects, leading to paralysis and death. It is generally considered to have low toxicity to humans and other mammals when used according to label instructions, but it is important to follow safety precautions and proper application techniques when using products containing this chemical. |
InChI:InChI=1/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
In this contribution, we demonstrate tha...
We report the synthesis of racetams, a d...
An exceedingly short and enantioselectiv...
A striking variety of anhydrous and hydr...
Chiral resolution of racemic etiracetam ...
Levetiracetam is an active pharmaceutica...
Identifying catalyst activation modes th...
The goal of this contribution is to guid...
Total synthesis of levetiracetam, an act...
Levetiracetam, a novel antiepileptic dru...
The multistep preparation of 11C-levetir...
An efficient enantioselective synthesis ...
The invention discloses a method for syn...
The present invention relates to regiose...
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
levetiracetam
| Conditions | Yield |
|---|---|
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(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid; With thionyl chloride; In methanol; at 45 ℃;
With ammonia; In methanol; at 20 ℃; under 2250.23 Torr; Product distribution / selectivity;
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78.4% |
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(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;
With ammonium hydroxide; In tetrahydrofuran; for 16h;
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75% |
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid; With ammonium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.5h;
With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 11h;
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72% |
|
With ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; water; at 0 - 20 ℃; for 12.5h;
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65% |
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;
With ammonium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; enantioselective reaction;
|
62% |
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid; With di-tert-butyl dicarbonate; In acetonitrile; at 10 - 15 ℃;
With pyridine; ammonium bicarbonate; In acetonitrile; at 10 - 20 ℃;
|
|
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Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2: ammonium hydroxide / water; tetrahydrofuran / 18.5 h / 0 - 20 °C / Inert atmosphere
With ammonium hydroxide; triethylamine; In tetrahydrofuran; water;
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(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt
levetiracetam
| Conditions | Yield |
|---|---|
|
(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt; With sodium hydroxide; In water; for 0.5h;
With chloroformic acid ethyl ester; In dichloromethane; at -10 ℃; for 2h;
With ammonia; In dichloromethane; at -15 - -10 ℃; for 2h; Solvent; Reagent/catalyst;
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85% |
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Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / 0.5 h / 0 - 10 °C
1.2: pH 4 - 5
2.1: toluene-4-sulfonic acid / 7 h / 60 °C
3.1: ammonia / 24 h / 0 - 10 °C
With ammonia; water; toluene-4-sulfonic acid; sodium hydroxide;
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α-ethyl-2-oxo-1-pyrrolidineacetic acid,
(R)-2-pyrrolidone-N-butyric acid
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
(S)-methyl 2-(2-oxopyrrolidin-1-yl)-2-butanoate
C8H8O3*C8H14N2O2
(2S)-2-(2-oxo-1-pyrrolidinyl)butanenitrile
α-ethyl-2-oxo-1-pyrrolidineacetamide
(R)-2-chloromandelic acid
