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  • Product NameAntide
  • CasNo. 112568-12-4
  • MFC82H108ClN17O14
  • MW1591.32
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Product Details

CasNo： 112568-12-4

MF： C82H108ClN17O14

Factory Supply Top Purity Antide 112568-12-4 Lowest Price

  • Molecular Formula:C82H108ClN17O14
  • Molecular Weight:1591.32
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.592 
  • Boiling Point:1798 °C at 760 mmHg 
  • PKA:12.78±0.46(Predicted) 
  • Flash Point:1041.2 °C 
  • PSA：454.43000 
  • Density:1.258 g/cm3 
  • LogP:8.32170 

Antide(Cas 112568-12-4) Usage

Description Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.

Uses

Reversible inhibition of gonadotropin secretion and subsequent suppression of ovarian and testicular steroid secretio (gonadotropin releasing hormone antagonist).

InChI:InChI=1/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+/m1/s1

112568-12-4 Relevant articles

Gonadotropin-Releasing Hormone Antagonists with Nω-Triazolylornithine, -lysine, or -p-aminophenylalanine Residues at Position 5 and 6

Rivier, Jean,Porter, John,Hoeger, Carl,Theobald, Paula,Craig, A. Grey,et al.

, p. 4270 - 4278 (2007/10/02)

In order to be used as fertility regulat...

Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men

Carrie J. Bagatell M.D. †, P. Michael Conn Ph.D., William J. Bremner M.D., Ph.D.

, Fertility and Sterility Volume 60, Issue 4, October 1993, Pages 680-685

We administered single injections of Nal-Lys (0, 10, 25, and 50 μ/kg body weight). Blood samples were collected before and at frequent time intervals after injection.

112568-12-4 Process route

Boc-DPal
98266-33-2,105454-25-9

Boc-DPal

N-Boc-D-(4-Cl)Phe-OH
57292-44-1

N-Boc-D-(4-Cl)Phe-OH

Boc-D-2Nal-OH
76985-10-9

Boc-D-2Nal-OH

(S)-3-(benzoyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid
78545-07-0

(S)-3-(benzoyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

antide
112568-12-4

antide

Conditions
Conditions Yield
Multistep reaction;
 

112568-12-4 Upstream products

  • 98266-33-2
    98266-33-2

    Boc-DPal

  • 57292-44-1
    57292-44-1

    N-Boc-D-(4-Cl)Phe-OH

  • 76985-10-9
    76985-10-9

    Boc-D-2Nal-OH

  • 78545-07-0
    78545-07-0

    (S)-3-(benzoyloxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

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