CasNo： 3106-85-2
MF： C11H16N2O8
Appearance： white powder
| Description | Spaglumic acid is a mast cell stabilizer. Mast cells are involved in producing an allergic response by releasing inflammatory mediators such as histamine. |
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Chemical Properties |
White powder |
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Uses |
Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain. In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. |
InChI:InChI=1/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1
A short, one-pot synthesis of α- and β-spaglumic acids (N-acetyl-L-aspartyl-L-glutamic acids, NAAGA) has been developed based on ultrasound-promoted acetylation of aspartic acid, followed by dehydration, condensation with glutamic acid dibenzyl ester and hydrogenolysis. The α- and β-peptides were separated by anion-exchange chromatography.
The α-isomer is predominantly formed in ...
Ac-Asp-Glu(Et)2
Ac-Asp(Bzl)-Glu(Bzl)2
N-acetyl-L-aspartic acid β-benzyl ester
L-glutamic acid
N-acetyl-aspartate
N-Acetyl-L-aspartic acid
