• Product NamePepstatin
  • CasNo. 26305-03-3
  • MFC34H63N5O9
  • MW685.902
  • Purity
  • Appearancesolid
  • Packing
  • Contact usInquiry

Product Details

CasNo: 26305-03-3

MF: C34H63N5O9

Appearance: solid

Factory Supply High Purity Pepstatin,Export 26305-03-3 In Bulk Supply

  • Molecular Formula:C34H63N5O9
  • Molecular Weight:685.902
  • Appearance/Colour:solid 
  • Melting Point:233 °C (dec.)(lit.) 
  • Refractive Index:1.7500 (estimate) 
  • Boiling Point:997.57 °C at 760 mmHg 
  • Flash Point:557.111 °C 
  • PSA:223.26000 
  • Density:1.118 g/cm3 
  • LogP:3.42170 

Pepstatin(Cas 26305-03-3) Usage

Description

Pepstatin is a potent inhibitor of aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine, having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta. It was originally isolated from cultures of various species of Actinomyces due to its ability to inhibit pepsin at picomolar concentrations.

Uses

Pepstatin is a peptide inhibitor isolated from cultures of Actinomycestes by Umezawa et al. (1970) and is widely used as a potent inhibitor of cathepsin E. Because this inhibitor is a general inhibitor of aspartic peptidases of the A1 family, however, it is not specific for cathepsin E.

26305-03-3 Relevant articles

Mode of inhibition of acid proteases by pepstatin.

J Marciniszyn Jr, J A Hartsuck, J Tang

, Journal of Biological Chemistry, Volume 251, Issue 22, 25 November 1976, Pages 7088-7094

It is suggested that the statyl residue is responsible for the unusual inhibitory capability of pepstatin and that statine is an analog of the previously proposed transition state for catalysis by pepsin and other acid proteases.

Synthesis and biochemical characterisation of fluorinated analogues of pepstatin A and grassystatin A

Lawer, Aggie,Nesvaderani, John,Marcolin, Gabriella M.,Hunter, Luke

, p. 1278 - 1287 (2018)

Pepstatin A and grassystatin A are natur...

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