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  • Product NameCaerulein ammonium salt
  • CasNo. 17650-98-5
  • MFC58H73 N13 O21 S2
  • MW1352.42
  • Purity
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Product Details

CasNo： 17650-98-5

MF： C58H73 N13 O21 S2

Factory Supply 99% Pure Caerulein ammonium salt 17650-98-5 Safe Shipping

  • Molecular Formula:C58H73 N13 O21 S2
  • Molecular Weight:1352.42
  • Melting Point:224-226° (dec) 
  • Boiling Point:°Cat760mmHg 
  • PKA:-4.17±0.18(Predicted) 
  • Flash Point:°C 
  • PSA：585.08000 
  • Density:1.406g/cm3 
  • LogP:1.81300 

Caerulein(Cas 17650-98-5) Usage

Discovery

Caerulein is a peptide secreted from the skin of frogs. Caerulein shares the conserved C-terminal sequence that is responsible for receptor activation with vertebrate gastrin and cholecystokinin (CCK), and functions as their agonist.?Caerulein was first described in a number of Australian amphibians as a polypeptide that stimulates pancreatic external secretion and elicits a decrease in blood pressure and extravascular smooth muscle contraction in mammals. Caerulein was first purified from the Australian tree frog Hyla caerulea in 1967.

Uses

Caerulein is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. It is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.

InChI:InChI=1/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49+/m1/s1

17650-98-5 Relevant articles

Isolation and amino acid sequence of caerulein, the active decapeptide of the skin of Hyla caerulea

A. Anastasi a b c, V. Erspamer a b c, R. Exdean a b c

, Archives of Biochemistry and Biophysics Volume 125, Issue 1, April 1968, Pages 57-68

Crude methanol extracts of dried skins of Hyla caerulea, an Australian amphibian, were subjected to several steps of countercurrent distribution and ion-exchange chromatography. The active constituent of these extracts, the peptide caerulein, was obtained in pure form.

Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis

Wei Huang a b, Andrea C. Haynes d, Rajarshi Mukherjee a b, Li Wen a b, Diane Latawiec a b, Alexei V. Tepikin b c, David N. Criddle b c, Rab K. Prinjha d, Nicholas Smithers d, Robert Sutton a b

, Pancreatology Volume 17, Issue 5, September–October 2017, Pages 689-697

TLCS-AP, FAEE-AP and CER-AP resulted in characteristic elevations in serum amylase and cytokine levels, increased pancreatic trypsin and myeloperoxidase activity, typical pancreatic histopathological changes and lung injury. Treatment with I-BET-762 significantly reduced biochemical, cytokine and histopathological responses in TLCS-AP and FAEE-AP, but not CER-AP.

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