CasNo： 87344-06-7
MF： C24H24N2O5
Appearance： white needle-shaped crystal
|
Description |
Amtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID) introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain. Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability. |
|
Originator |
Sigma Tau (Italy) |
|
Uses |
Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis, |
|
Brand name |
Artromed |
InChI:InChI=1/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)
Efforts toward the synthesis and process...
2-methoxy-phenol
Tolmetin glycine amide
amtolmetin guacil
| Conditions | Yield |
|---|---|
|
With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 25 - 30 ℃; Large scale reaction;
|
74.8% |
amino acetic acid guacil ester hydrochloride
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
amtolmetin guacil
| Conditions | Yield |
|---|---|
|
With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetone; at -5 - 30 ℃; for 5h;
|
60% |
N-Methylpyrrole
1-methylpyrrole-2-acetic acid
tert-butyloxycarbonylamino acetic acid guacil ester
C18H20N2O4
