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CasNo: 489-32-7
MF: C33H40O15
Description |
Icariin is a flavonoid glucoside that is isolated from Epimedium spp (Berberidaceae) (Shen et al., 2015) and is considered as a primary active compound of Epimedium extracts with neuroprotective and estrogen-like effects (Becher et al., 2002). |
Chemical Properties |
Light yellow to yellow solid |
Uses |
Icariin is a biologically active substance in Epimedii herba that is used for the treatment of neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of icariin is lacking. |
InChI:InChI=1/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
Treatment of icariin for 21 consecutive days mainly reversed the above effects in the mouse FST. These results suggested that icarrin possessed potent antidepressant-like properties that were mediated via neurochemical and neuroendocrine systems.
Icariin (1a), a 7-O-glycosylated flavono...
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